Therapeutic Nanoparticle Systems Targeting Smooth Muscle Cells in Cardiovascular Diseases: A Review

E. Mohammadi ^a, Akbari ^a,b,c, S. Heydarali ^a, A. Akbari ^c

Smooth muscle cells (SMCs), as a crucial component of blood vessel walls, play a key role in their structural integrity and functional regulation. They are also involved in maintaining blood pressure, regulating blood flow, and modulating the immune response. However, various factors can trigger a phenotypic shift in SMCs, leading to dysregulation and dysfunction. Such alterations cause the development of numerous cardiovascular disorders. Addressing these types of diseases is of a great importance due to their high prevalence across many societies. Development of nanotechnology has a great contribution in developing advanced and more effective therapeutic strategies for cardiovascular diseases. In this article, we present a comprehensive overview of recent research progress in the field of drug and gene delivery to SMCs. Our aim is to offer valuable insights and guidance for future research endeavors, ultimately contributing to the development of more effective therapeutic approaches for managing cardiovascular disorders.

^aNanoSciTec GmbH, Hermann Weinhauser str. 67, Munich, 81867, Germany

^c BioMedEx GmbH, weyringerg 37 Stiege 1, 1040, Vienna, Austria

^c GreenNanoTech Kft, Westend Business Center, 22-24 Váci street, Budapest, 1132, Hungary

Corresponding author: A. Akbari. Tel.: +36-20-453-7574 E-mail address: armita.akbari@greennanotec.com

Keywords: Smooth muscle cells, Cardiovascular diseases, Drug delivery, Gene Delivery

© Article info: Accepted by: 14 August 2024, Published by 30 August 2024.

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